Cardiovascular Risk
CV
+4
Sep 15, 2026
•
10 min read
The Pain Is Real. The Statin Isn't.
Blinded trials show most muscle symptoms blamed on statins are not caused by the statin. A real minority are. SAMSON, StatinWISE, GAUSS-3, and 123,940 pooled patients measured the difference.
CV
+4
Sep 12, 2026
•
10 min read
Low Calculated Risk. Plaque Already Present.
REACT imaged 16,808 adults aged 18 to 70. More than half had atherosclerotic plaque, and a low ten-year risk estimate did not establish that arteries were plaque-free. Whether finding plaque earlier changes outcomes is still being tested.
Lp(a)
+4
Sep 5, 2026
•
8 min read
The Drug Worked. The Trial Failed.
Pelacarsen lowered Lp(a) in 8,323 patients with established cardiovascular disease. It did not prevent events. What Lp(a)HORIZON teaches about the 1 in 5 — and what it can't.
CV
+4
Aug 18, 2026
•
14 min read
It's Already on Every Panel. Nobody Reads It.
Remnant cholesterol costs nothing to calculate and predicts events when LDL no longer does. Its first real drug just proved it can prevent pancreatitis, and then failed to move plaque.
